Endocrine Abstracts

Background: Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as anterior pituitary deficiency. Although pituitary gland metastasis is rare, it is underestimated, as it is commonly misdiagnosed with pituitary gland adenoma due to the lack of clear r...

Introduction: Sheehan syndrome represents a rare cause of hypopituitarism. It results from postpartum ischemic necrosis of the pituitary gland. Data evaluating the quality of life in women with Sheehan syndrome are scarce. The aim of this study was to assess the quality of life in patients with Sheehan syndrome and to determine its associated factors.Methods: A cross-sectional study including women with Sheehan syndrome was conducted in the department of...

Introduction: The majority of systemic diseases result from an autoimmune process. Primary adrenal insufficiency (Addisson’s disease AD) is also frequently caused by an autoimmune process. Their association is rare but can be seen in the framework of autoimmune polyendocrinopathies. We report 2 observations associating an autoimmune adrenal insufficiency with a systemic disease.Observation 1: We describe the case of a 50-year-old patient initially a...

Introduction: Double Pituitary adenomas with growth hormone (GH) and adrenocorticotropic hormone (ACTH) secretion are very rare. They are responsible for acromegaly with hypercortisolism. Subclinical corticotropic adenomas are exceptional. Herein, we report the case of a patient with double functional pituitary adenomas causing acromegaly and subclinical Cushing’s disease.Observation: A 45-year-old woman was referred to our department for suspected ...

Introduction: Sarcoidosis may affect the central and peripheral nervous systems in 5–16% of patients. In most cases, such involvement occurs within a multi-systemic disease. Neurological involvement is rare but a potentially life-threatening form of sarcoidosis. The endocrine manifestations of neurosarcoidosis include hypothalamic dysfunction, diabetes insipidus, hypopituitarism, and amenorrhea–galactorrhea syndrome. Herein, we report the case of a patient with hypop...

Introduction: Central diabetes insipidus is a rare condition that typically manifests as polyuria-polydipsia syndrome. Polydipsia helps to maintain normal natremia. Herein, we report the case of persistent hypernatremia in a patient admitted for inaugural diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome.Observation : A 53-year-old woman was referred to our department for inaugural diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome...

Introduction: Leydig cell tumor is rare, accounting for 1% of testicular tumors. Klinefelter syndrome is most often associated with extra-gonadal germ cell tumors. Its association with testicular tumors remains less frequent. Herein, we report the case of a Leydig cell tumor of the testis in a patient with Klinefelter syndrome.Observation: A 46-year-old man was referred to our department for hypogonadism. His past medical history included type 2 diabetes...

Introduction: Cardiovascular diseases are frequent in patients with hypopituitarism receiving conventional hormone replacement therapy. They represent the main cause of premature death in this population. Emerging evidence smggests that beyond traditional risk factors, evaluating coronary calcium score (CCS) and inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) provides valuable insights into cardiovascular health in this population. The aims of the pre...

Introduction: The interplay between type 2 diabetes (T2D), male hypogonadism (HG), and inflammation has emerged as a fascinating area of medical research. Understanding the complex relationship among these factors is crucial for advancing our knowledge.Methods: The study focused on 250 adult male patients with T2D recruited from outpatient clinics at the National Institute of Nutrition and Food Technology. A thorough assessment of gonadal hormones, inclu...

Introduction: Patients with Sheehan’s syndrome (SS) may experience alterations in blood pressure (BP) regulation, possibly due to hormones deficiencies and hormone replacement treatment. The aim of the present study was to assess the 24h ambulatory BP in women with Sheehan syndrome.Methods: This was a monocentric cross-sectional study involving 50 women with complete anterior hypopituitarism secondary to SS and 50 age and body-mass index (BMI) match...